The following list of cancer immunotherapies are available for licensing under U.S. Patent Publication No.: 20220370499.
Immunotherapies for Targeting of Tumor Vasculature
Abstract
Disclosed are novel means, protocols, and compositions of matter for creating targeted immune responses and/or induction of immunological memory towards the tumor vasculature. In one embodiment pluripotent stem cells are transfected with one or more genes capable of eliciting immunity, induced to differentiate into endothelial-like cells which resemble the tumor endothelial cells, and utilized as a vaccine. In some embodiment’s genes are engineered under control of specific promoters to allow for various specificities of activity. In one specific embodiment pluripotent stem cells engineered to endow properties capable of inducing expression of the α-Gal epitope (Galα1,3Galα1,4GlcNAc-R). Addition of adjuvants to enhance antigen presentation of the vaccine composition, as well as means of stimulating systemic enhancement of circulating endothelial specific T cells are also disclosed.
Cancer of the Brain is a growth of abnormal cells in the brain. There are more than 120 different types of tumors that can develop in the brain.
| Upfront Fee | Annual Minimum Royalty | Phase 1 IND | Phase 2 IND | Phase 3 IND | BLA | Royalty |
|---|---|---|---|---|---|---|
| $50,000 | $10,000 | $100,000 | $250,000 | $500,000 | $1,000,000 | 6% |
Melanoma is a kind of skin cancer that starts in the melanocytes. Melanocytes are cells that make the pigment that gives skin its color. The pigment is called melanin. Melanoma typically starts on skin that’s often exposed to the sun. This includes the skin on the arms, back, face and legs.
| Upfront Fee | Annual Minimum Royalty | Phase 1 IND | Phase 2 IND | Phase 3 IND | BLA | Royalty |
|---|---|---|---|---|---|---|
| $50,000 | $10,000 | $100,000 | $250,000 | $500,000 | $1,000,000 | 6% |
Bladder cancer is a common type of cancer that begins in the cells of the bladder.
| Upfront Fee | Annual Minimum Royalty | Phase 1 IND | Phase 2 IND | Phase 3 IND | BLA | Royalty |
|---|---|---|---|---|---|---|
| $50,000 | $10,000 | $100,000 | $250,000 | $500,000 | $1,000,000 | 6% |
Breast cancer is a disease in which abnormal breast cells grow out of control and form tumours. If left unchecked, the tumours can spread throughout the body and become fatal. Breast cancer cells begin inside the milk ducts and/or the milk-producing lobules of the breast.
| Upfront Fee | Annual Minimum Royalty | Phase 1 IND | Phase 2 IND | Phase 3 IND | BLA | Royalty |
|---|---|---|---|---|---|---|
| $50,000 | $10,000 | $100,000 | $250,000 | $500,000 | $1,000,000 | 6% |
Cervical cancer is a growth of cells that starts in the cervix. The cervix is the lower part of the uterus that connects to the vagina. Various strains of the human papillomavirus, also called HPV, play a role in causing most cervical cancers.
| Upfront Fee | Annual Minimum Royalty | Phase 1 IND | Phase 2 IND | Phase 3 IND | BLA | Royalty |
|---|---|---|---|---|---|---|
| $50,000 | $10,000 | $100,000 | $250,000 | $500,000 | $1,000,000 | 6% |
Colon cancer develops from polyps in your colon’s inner lining. Screening tests and newer treatments are helping more people survive colon cancer.
| Upfront Fee | Annual Minimum Royalty | Phase 1 IND | Phase 2 IND | Phase 3 IND | BLA | Royalty |
|---|---|---|---|---|---|---|
| $50,000 | $10,000 | $100,000 | $250,000 | $500,000 | $1,000,000 | 6% |
Head and neck cancer symptoms may include a sore in the mouth and pain when swallowing.
| Upfront Fee | Annual Minimum Royalty | Phase 1 IND | Phase 2 IND | Phase 3 IND | BLA | Royalty |
|---|---|---|---|---|---|---|
| $50,000 | $10,000 | $100,000 | $250,000 | $500,000 | $1,000,000 | 6% |
Kidney cancer is a type of cancer that starts in the kidney when cells in the body begin to grow out of control.
| Upfront Fee | Annual Minimum Royalty | Phase 1 IND | Phase 2 IND | Phase 3 IND | BLA | Royalty |
|---|---|---|---|---|---|---|
| $50,000 | $10,000 | $100,000 | $250,000 | $500,000 | $1,000,000 | 6% |
Lung cancer is cancer that forms in tissues of the lung, usually in the cells that line the air passages. It is the leading cause of cancer death in both men and women. There are two main types: small cell lung cancer and non-small cell lung cancer. These two types grow differently and are treated differently.
| Upfront Fee | Annual Minimum Royalty | Phase 1 IND | Phase 2 IND | Phase 3 IND | BLA | Royalty |
|---|---|---|---|---|---|---|
| $50,000 | $10,000 | $100,000 | $250,000 | $500,000 | $1,000,000 | 6% |
Non-small cell lung cancer is a group of lung cancers that behave similarly, such as squamous cell carcinoma and adenocarcinoma. Symptoms are a cough that won’t go away, shortness of breath, weight loss, or coughing up blood.
| Upfront Fee | Annual Minimum Royalty | Phase 1 IND | Phase 2 IND | Phase 3 IND | BLA | Royalty |
|---|---|---|---|---|---|---|
| $50,000 | $10,000 | $100,000 | $250,000 | $500,000 | $1,000,000 | 6% |
Mesothelioma is a rare condition that involves tumors growing in the mesothelium. This tissue covers the lungs, the heart and reproductive organs, as well as forming a cavity for the abdomen and those organs.
| Upfront Fee | Annual Minimum Royalty | Phase 1 IND | Phase 2 IND | Phase 3 IND | BLA | Royalty |
|---|---|---|---|---|---|---|
| $50,000 | $10,000 | $100,000 | $250,000 | $500,000 | $1,000,000 | 6% |
Ovarian cancer is a growth of cells that forms in the ovaries. The cells multiply quickly and can invade and destroy healthy body tissue.
| Upfront Fee | Annual Minimum Royalty | Phase 1 IND | Phase 2 IND | Phase 3 IND | BLA | Royalty |
|---|---|---|---|---|---|---|
| $50,000 | $10,000 | $100,000 | $250,000 | $500,000 | $1,000,000 | 6% |
Prostate cancer is one of the most common types of cancer among American men. The risk goes up as men age.
| Upfront Fee | Annual Minimum Royalty | Phase 1 IND | Phase 2 IND | Phase 3 IND | BLA | Royalty |
|---|---|---|---|---|---|---|
| $50,000 | $10,000 | $100,000 | $250,000 | $500,000 | $1,000,000 | 6% |
Stomach cancer, also known as gastric cancer, is a cancer that develops from the lining of the stomach.
| Upfront Fee | Annual Minimum Royalty | Phase 1 IND | Phase 2 IND | Phase 3 IND | BLA | Royalty |
|---|---|---|---|---|---|---|
| $50,000 | $10,000 | $100,000 | $250,000 | $500,000 | $1,000,000 | 6% |
Uterus or uterine cancer is also called endometrial cancer because it forms in the lining of your uterus, called the endometrium. All women are at risk for uterine cancer as long as they have a uterus, and the risk increases with age.
| Upfront Fee | Annual Minimum Royalty | Phase 1 IND | Phase 2 IND | Phase 3 IND | BLA | Royalty |
|---|---|---|---|---|---|---|
| $50,000 | $10,000 | $100,000 | $250,000 | $500,000 | $1,000,000 | 6% |
Medulloblastoma is a type of brain cancer that starts in the part of the brain called the cerebellum. Medulloblastoma is the most common type of cancerous brain tumor in children. Medulloblastoma (muh-dul-o-blas-TOE-muh) is a cancerous brain tumor that starts in the lower back part of the brain.
| Upfront Fee | Annual Minimum Royalty | Phase 1 IND | Phase 2 IND | Phase 3 IND | BLA | Royalty |
|---|---|---|---|---|---|---|
| $50,000 | $10,000 | $100,000 | $250,000 | $500,000 | $1,000,000 | 6% |