The following list of cancer immunotherapies are available for licensing under U.S. Patent Publication No.: 20220403330.

Compositions Capable of Stimulating Immunity Towards Tumor Blood Vessels

Abstract
Disclosed are novel means, protocols, and compositions of matter for eliciting an immune response against blood vessels supplying neoplastic tissue. In one embodiment pluripotent stem cells are transfected with one or more genes capable of eliciting immunity. In some embodiments such genes are engineered under control of specific promoters to allow for various specificities of activity. In one specific embodiment pluripotent stem cells engineered to endow properties capable of inducing expression of the α-Gal epitope (Galα1,3Galα1,4G1cNAc-R).







Hodgkin’s disease, also known as Hodgkin lymphoma, is a rare cancer that affects the lymphatic system and is part of the immune system.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Non-hodgkin’s lymphoma is a blood cancer that occurs when malignant cells form in the lymphatic system. The lymphatic system is part of the immune system and is made up of vessels and glands that carry lymph, a fluid containing white blood cells that fight infection. In NHL, lymphocytes multiply abnormally and collect in the lymphatic system, losing their ability to fight infection.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Multiple myeloma, also known as plasma cell myeloma, is a blood cancer that occurs when plasma cells in the bone marrow grow out of control. Plasma cells are a type of white blood cell that produce antibodies to help the immune system fight infections.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Neuroblastoma is a type of cancer that forms in immature nerve cells, or neuroblasts, in the adrenal glands, neck, chest, abdomen, or spine.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Breast cancer is a disease that occurs when breast cells grow out of control and form tumors. It’s the second most common type of cancer in women in the United States, and can also rarely affect men.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Ovarian cancer is a type of cancer that forms in the ovaries, fallopian tubes, or peritoneum. It can originate from the ovaries themselves or nearby structures, such as the fallopian tubes or the lining of the abdomen.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Lung cancer is a malignant tumor that starts in the lungs, usually in the cells that line the air passages. It’s the leading cause of cancer deaths in both men and women.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Rhabdomyosarcoma is a rare type of cancer that starts as a growth of cells in soft tissue. Soft tissues support and connect organs and other parts of the body. Rhabdomyosarcoma most often starts in muscle tissue.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Primary thrombocytosis is a blood and bone marrow disease. A high platelet level may be detected in a routine blood test known as a complete blood count.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Primary macroglobulinemia, also known as Waldenström macroglobulinemia, is a rare plasma cell cancer that causes the body to produce too many macroglobulins, a type of antibody.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Small-cell lung tumors is an aggressive and fast-growing type of lung cancer that usually starts in the breathing tubes in the center of the chest.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Primary brain tumors are tumors that originate in the brain or spinal cord, and can be benign or malignant.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Stomach cancer, also known as gastric cancer, is a type of cancer that develops in the lining of the stomach. It’s caused by changes in how stomach cells grow and divide.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Colon cancer, also known as colorectal cancer, is a type of cancer that develops in the colon or rectum. It’s a leading cause of cancer deaths in the United States.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Malignant pancreatic insulanoma is a rare, cancerous tumor that can spread from the pancreas to other parts of the body.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Malignant carcinoid are rare, slow-growing tumors that can spread to other parts of the body.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Premalignant skin lesions are changes to skin cells that increase the likelihood of developing skin cancer.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Testicular cancer is a rare disease that occurs when malignant cells form in the tissues of one or both testicles.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Lymphoma is a type of blood cancer that affects the lymphatic system and immune system. It occurs when white blood cells called lymphocytes mutate and multiply abnormally, disrupting the lymph nodes’ normal function.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Thyroid cancer is a rare cancer that occurs when malignant cells form in the thyroid gland, a butterfly-shaped gland in the neck that produces hormones.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Neuroblastoma is a type of cancer that forms in immature nerve cells, or neuroblasts, in the adrenal glands, neck, chest, abdomen, or spine.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Esophageal cancer is a rare cancer that forms in the tissues of the esophagus, the muscular tube that moves food and liquids from the throat to the stomach.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Genitourinary tract cancer are cancers that affect the urinary system and reproductive organs.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Malignant hypercalcemia is the most common life-threatening metabolic disorder associated with cancer.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Cervical cancer is a type of cancer that originates in the cervix, the opening of the uterus, and is almost always caused by a persistent infection with the human papillomavirus (HPV), which spreads through sexual contact.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Endometrial cancer, also known as uterine cancer, is a cancer that develops in the lining of the uterus. It’s caused by abnormal cell growth that can spread to other parts of the body.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Adrenal cortical cancer is a rare and aggressive cancer that forms in the adrenal cortex, the outer layer of the adrenal glands.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%