The following list of cancer immunotherapies are available for licensing under U.S. Patent Publication No.: 20220096542.

Augmentation of Natural Killer Cell Activity and Induction of Cytotoxic Immunity Using Leukocyte Lysate Activated Allogeneic Dendritic Cells: StemVacs

Abstract
Stimulation of immunity would be beneficial in various chronic conditions such as viral infections and neoplasia. Autologous dendritic cell therapy has been widely described in the immunotherapy literature and has been approved by the FDA for treatment of prostate cancer. Unfortunately, the need to generate individual doses is costly and limited by ability of the patients to have sufficient starting cell numbers available to generate sufficient dendritic cells. Here we describe the process of preparing allogeneic dendritic cells utilizing a leukocyte lysate based approach. These data support development of StemVacs for conditions that would benefit from NK activation such as cancer and COVID-19..







Chondrosarcoma is a rare, malignant (cancerous) bone tumor made up of cartilage cells, the firm tissue that protects the ends of bones. These bone sarcomas usually start in the pelvis, chest, arms, or legs. They can grow fairly large—often bigger than 4 centimeters across.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Fibrosarcomas are defined as malignant neoplasms composed of fibroblasts that may have varying amounts of collagen production and a “herringbone” architecture. Depending upon the origin, there are 2 main categories of fibrosarcomas: bone and soft tissue tumors.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Lymphosarcoma is highly malignant and, while the individual tumor may be affected by radiation, the course of the disease is usually progressive. Lymphosarcoma may arise in any organ which has a basic reticulum structure, i.e. lymphoid tissue, spleen, liver, or bone marrow.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Melano sarcoma is a type of cancer that can occur in various locations in your body. Sarcoma is the general term for a broad group of cancers that begin in the bones.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Myxosarcomas are neoplasms of fibroblast origin with abundant myxoid matrix of mucopolysaccharides.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Osteosarcoma (osteogenic sarcoma) is a type of cancer that starts in your bones. In the beginning, the cancer cells appear to be regular bone cells. Then, they create tumors, and those tumors create immature, irregular, diseased bone.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Endometrial sarcoma is a very rare type of uterine cancer, with characteristics of both endometrial cancer and uterine sarcoma.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Stromal sarcoma (ESS) is a rare malignant tumor of the endometrium, occurring in the age group of 40–50 years.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Ewing’S sarcoma is a type of tumor that forms from a certain kind of cell in bone or soft tissue. Undifferentiated small round cell sarcoma may also form in the bone or soft tissue.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Fascial sarcoma may develop in the muscles, fascia (the tough membrane surrounding muscles), tendons, fat, blood vessels, nerves, etc.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Fibroblastic sarcoma is a type of soft tissue sarcoma that begins due to the formation of abnormal mass in fibrous tissue.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Giant cell sarcoma is one of the most common benign bone tumors, predominantly occurring in young adults aged 20 to 40 with a high recurrence rate and the potential for aggressive behavior. Typically found at the metaphyseal or epiphyseal regions of the tibia or femur, GCT, despite its predominantly benign nature, exhibits a highly unpredictable spectrum of disease behavior.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Abemethy’s sarcoma carries a high risk of hepatocellular carcinoma.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Adipose sarcoma is a cancer made up of fat cells, usually as a soft tissue sarcoma deep in the abdomen (belly), buttocks, arms, or legs. Liposarcomas may also occur as a rare esophageal cancer. Liposarcomas mostly affect middle-aged adults, from 50 to 65.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Liposarcoma is a rare type of cancer that develops in your fatty tissue. This type of tumor can grow anywhere in your body. Common places include your abdomen, thigh, and behind your knee. A liposarcoma is a malignant tumor. This means your cancer can spread to other areas, including vital organs.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Alveolar soft part sarcoma or ASPS, is a cancer that can come from different types of soft tissue, such as muscle, fat, or nerves.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Ameloblastic sarcoma is a rare malignant (cancerous) tumor that normally begins in the bones of the jaw.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Botryoid sarcoma is a variant of embryonal rhabdomyosarcoma that is characterized by the presence of a round, grape-like mass in the affected organ.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Chloroma sarcoma is a rare solid tumor composed of primitive precursors of the granulocytic series of WBC that include myeloblasts, promyelocytes, and myelocytes. This tumor was first described by Burns in 1811.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Chorio carcinoma is a malignant, fast-growing tumor that develops from trophoblastic cells (cells that help an embryo attach to the uterus and help form the placenta). Almost all choriocarcinomas form in the uterus after fertilization of an egg by a sperm, but a small number form in a testis or an ovary.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Embryonal sarcoma of the liver (UESL) is an aggressive malignancy that most commonly affects the pediatric age group.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Wilns’ tumor sarcoma is a type of childhood cancer that starts in the kidneys. It is the most common type of kidney cancer in children. About 9 of 10 kidney cancers in children are Wilms tumors. Cancer starts when cells in the body begin to grow out of control.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Granulocytic sarcoma is a rare type of cancer that is made up of myeloblasts (a type of immature white blood cell) and forms outside the bone marrow and blood.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Hodgkin’s sarcoma begins when healthy cells in the lymphatic system change and grow out of control. The lymphatic system includes lymph nodes.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Idiopathic multiple pigmented hemorrhagic sarcoma is characterized by red-purple or blue-brown lesions of the skin, mucous membranes, and other organs.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Immunoblastic sarcoma of b cells is a large cell lymphoma conceptually related to transformed T and B lymphocytes of the extrafollicular compartment of the immune system (immunoblasts).

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Lymphoma is a broad term for cancer that begins in cells of the lymph system. The two main types are Hodgkin lymphoma and non-Hodgkin lymphoma (NHL). Hodgkin lymphoma can often be cured. The prognosis of NHL depends on the specific type.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Immunoblastic sarcoma of t-cells is a large cell lymphoma conceptually related to transformed T and B lymphocytes of the extrafollicular compartment of the immune system (immunoblasts).

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Kaposi’s sarcoma is a type of cancer that forms in the lining of blood vessels and lymph vessels. The cancer forms growths of cells, called lesions, on the skin. The lesions often form on the face, arms and legs. The lesions may look pink, red, purple or brown.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Kupffer cell sarcomas form multiple gray macroscopic nodules that occur randomly through the liver. Histologically, they are composed of macrophage-like cells characterized by a pale, oval, indented nucleus surrounded by an abundant vacuolated cytoplasm.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Angiosarcoma is cancer that forms in the lining of blood vessels and lymph vessels. It often affects the skin and may appear as a bruise-like lesion that grows over time. Treatment depends on where the cancer is located.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Leukosarcoma is a type of rare cancer that grows in the smooth muscles. The smooth muscles are in the hollow organs of the body.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Malignant mesenchymoma sarcoma is a very rare type of cancer called a sarcoma. It: often grows in soft tissues, blood vessels, or organs like the intestines. mostly affects middle-aged adults.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Parosteal sarcoma s a subtype of osteosarcoma and arises from the outer layer of the periosteum.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Reticulocytic sarcoma, Like other dendritic cell sarcomas, fibroblastic reticular cell sarcomas affect adults and have been described in lymph nodes, spleen, and soft tissues.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Serocystic sarcoma are mostly benign lesions. Their incidence has increased recently due to the improvements in imaging techniques.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Synovial sarcoma is a cancer that can come from different types of soft tissue, such as muscle or ligaments. It is often found in the arm, leg, or foot, and near joints such as the wrist or ankle. It can also form in soft tissues in the lung or abdomen. Synovial sarcoma may also be called malignant synovioma.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%

Telangiectaltic sarcoma is a rare high-grade malignant neoplasm, accounting for less than 10 percent of all cases of osteosarcoma.

Upfront Fee Annual Minimum Royalty Phase 1 IND Phase 2 IND Phase 3 IND BLA Royalty
$50,000 $10,000 $100,000 $250,000 $500,000 $1,000,000 6%