{"id":215,"date":"2024-10-06T11:30:00","date_gmt":"2024-10-06T11:30:00","guid":{"rendered":"https:\/\/dev.therapeuticsolutionsint.com\/?page_id=215"},"modified":"2024-10-24T22:56:48","modified_gmt":"2024-10-24T22:56:48","slug":"stemvacs-l","status":"publish","type":"page","link":"https:\/\/stemvacs.therapeuticsolutionsint.com\/index.php\/stemvacs-l\/","title":{"rendered":"StemVacs-L"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Header&#8221; _builder_version=&#8221;4.21.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;gcid-3cfc8c0c-5557-4a5d-9dab-24e78d615311&#8243; custom_padding=&#8221;61px|||||&#8221; collapsed=&#8221;on&#8221; global_colors_info=&#8221;{%22gcid-3cfc8c0c-5557-4a5d-9dab-24e78d615311%22:%91%22background_color%22%93}&#8221;][et_pb_row _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px||0px|||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;-47px|||||&#8221; custom_padding=&#8221;2px||0px|||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>The following list of <strong>cancer immunotherapies<\/strong> are available for licensing under <a href=\"https:\/\/patents.justia.com\/patent\/20220096542\" target=\"_blank\" rel=\"noopener\">U.S. Patent Publication No.: <span>20220096542<\/span><\/a><span>.<\/span><\/p>\n<p><strong>Augmentation of Natural Killer Cell Activity and Induction of Cytotoxic Immunity Using Leukocyte Lysate Activated Allogeneic Dendritic Cells: StemVacs<\/strong><\/p>\n<p>Abstract<br \/>Stimulation of immunity would be beneficial in various chronic conditions such as viral infections and neoplasia. Autologous dendritic cell therapy has been widely described in the immunotherapy literature and has been approved by the FDA for treatment of prostate cancer. Unfortunately, the need to generate individual doses is costly and limited by ability of the patients to have sufficient starting cell numbers available to generate sufficient dendritic cells. Here we describe the process of preparing allogeneic dendritic cells utilizing a leukocyte lysate based approach. These data support development of StemVacs for conditions that would benefit from NK activation such as cancer and COVID-19..<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;-99px|auto||auto||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;-149px|||||&#8221; custom_padding=&#8221;105px|||||&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<html><br \/>\n<head><br \/>\n<script src=\"https:\/\/ajax.googleapis.com\/ajax\/libs\/jquery\/1.12.4\/jquery.min.js\"><\/script><br \/>\n<script>\n        $(function() {\n            $('.info').hide();\n            $('#lungList').on('change', function() {\n                $('.info').hide();\n                var lungCode = $('#lungList').val();\n                $('.info.' + lungCode).show();\n            });\n        });\n    <\/script><\/p>\n<p><select id=\"lungList\"><option value=\"\">[Select Disease]<\/option><option value=\"2\">Cancer of the Brain<\/option><option value=\"3\">Melanoma<\/option><option value=\"4\">Bladder<\/option><option value=\"5\">Breast<\/option><option value=\"6\">Cervix<\/option><option value=\"7\">Colon<\/option><option value=\"8\">Head and Neck<\/option><option value=\"9\">Kidney<\/option><option value=\"10\">Lung<\/option><option value=\"11\">Non-Small Cell Lung<\/option><option value=\"12\">Mesothelioma<\/option><option value=\"13\">Ovary<\/option><option value=\"14\">Prostate<\/option><option value=\"15\">Stomach<\/option><option value=\"16\">Uterus<\/option><option value=\"17\">Medulloblastoma<\/option><\/select><\/p>\n<div class=\"info 2\">\n<table style=\"width: 100%;\"><\/table>\n<p>Cancer of the Brain is a growth of abnormal cells in the brain. There are more than 120 different types of tumors that can develop in the brain.<\/p>\n<table style=\"width: 100%;\">\n<tbody>\n<tr>\n<th>Upfront Fee<\/th>\n<th>Annual Minimum Royalty<\/th>\n<th>Phase 1 IND<\/th>\n<th>Phase 2 IND<\/th>\n<th>Phase 3 IND<\/th>\n<th>BLA<\/th>\n<th>Royalty<\/th>\n<\/tr>\n<tr>\n<td>$50,000<\/td>\n<td>$10,000<\/td>\n<td>$100,000<\/td>\n<td>$250,000<\/td>\n<td>$500,000<\/td>\n<td>$1,000,000<\/td>\n<td>6%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"info 3\">\n<table style=\"width: 100%;\"><\/table>\n<p>Melanoma is a kind of skin cancer that starts in the melanocytes. Melanocytes are cells that make the pigment that gives skin its color. The pigment is called melanin. Melanoma typically starts on skin that&#8217;s often exposed to the sun. This includes the skin on the arms, back, face and legs.<\/p>\n<table style=\"width: 100%;\">\n<tbody>\n<tr>\n<th>Upfront Fee<\/th>\n<th>Annual Minimum Royalty<\/th>\n<th>Phase 1 IND<\/th>\n<th>Phase 2 IND<\/th>\n<th>Phase 3 IND<\/th>\n<th>BLA<\/th>\n<th>Royalty<\/th>\n<\/tr>\n<tr>\n<td>$50,000<\/td>\n<td>$10,000<\/td>\n<td>$100,000<\/td>\n<td>$250,000<\/td>\n<td>$500,000<\/td>\n<td>$1,000,000<\/td>\n<td>6%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"info 4\">\n<table style=\"width: 100%;\"><\/table>\n<p>Bladder cancer is a common type of cancer that begins in the cells of the bladder.<\/p>\n<table style=\"width: 100%;\">\n<tbody>\n<tr>\n<th>Upfront Fee<\/th>\n<th>Annual Minimum Royalty<\/th>\n<th>Phase 1 IND<\/th>\n<th>Phase 2 IND<\/th>\n<th>Phase 3 IND<\/th>\n<th>BLA<\/th>\n<th>Royalty<\/th>\n<\/tr>\n<tr>\n<td>$50,000<\/td>\n<td>$10,000<\/td>\n<td>$100,000<\/td>\n<td>$250,000<\/td>\n<td>$500,000<\/td>\n<td>$1,000,000<\/td>\n<td>6%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"info 5\">\n<p>Breast cancer is a disease in which abnormal breast cells grow out of control and form tumours. If left unchecked, the tumours can spread throughout the body and become fatal. Breast cancer cells begin inside the milk ducts and\/or the milk-producing lobules of the breast.<\/p>\n<table style=\"width: 100%;\">\n<tbody>\n<tr>\n<th>Upfront Fee<\/th>\n<th>Annual Minimum Royalty<\/th>\n<th>Phase 1 IND<\/th>\n<th>Phase 2 IND<\/th>\n<th>Phase 3 IND<\/th>\n<th>BLA<\/th>\n<th>Royalty<\/th>\n<\/tr>\n<tr>\n<td>$50,000<\/td>\n<td>$10,000<\/td>\n<td>$100,000<\/td>\n<td>$250,000<\/td>\n<td>$500,000<\/td>\n<td>$1,000,000<\/td>\n<td>6%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"info 6\">\n<table style=\"width: 100%;\"><\/table>\n<p>Cervical cancer is a growth of cells that starts in the cervix. The cervix is the lower part of the uterus that connects to the vagina. Various strains of the human papillomavirus, also called HPV, play a role in causing most cervical cancers.<\/p>\n<table style=\"width: 100%;\">\n<tbody>\n<tr>\n<th>Upfront Fee<\/th>\n<th>Annual Minimum Royalty<\/th>\n<th>Phase 1 IND<\/th>\n<th>Phase 2 IND<\/th>\n<th>Phase 3 IND<\/th>\n<th>BLA<\/th>\n<th>Royalty<\/th>\n<\/tr>\n<tr>\n<td>$50,000<\/td>\n<td>$10,000<\/td>\n<td>$100,000<\/td>\n<td>$250,000<\/td>\n<td>$500,000<\/td>\n<td>$1,000,000<\/td>\n<td>6%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"info 7\">\n<table style=\"width: 100%;\"><\/table>\n<p>Colon cancer develops from polyps in your colon&#8217;s inner lining. Screening tests and newer treatments are helping more people survive colon cancer.<\/p>\n<table style=\"width: 100%;\">\n<tbody>\n<tr>\n<th>Upfront Fee<\/th>\n<th>Annual Minimum Royalty<\/th>\n<th>Phase 1 IND<\/th>\n<th>Phase 2 IND<\/th>\n<th>Phase 3 IND<\/th>\n<th>BLA<\/th>\n<th>Royalty<\/th>\n<\/tr>\n<tr>\n<td>$50,000<\/td>\n<td>$10,000<\/td>\n<td>$100,000<\/td>\n<td>$250,000<\/td>\n<td>$500,000<\/td>\n<td>$1,000,000<\/td>\n<td>6%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"info 8\">\n<table style=\"width: 100%;\"><\/table>\n<p>Head and neck cancer symptoms may include a sore in the mouth and pain when swallowing.<\/p>\n<table style=\"width: 100%;\">\n<tbody>\n<tr>\n<th>Upfront Fee<\/th>\n<th>Annual Minimum Royalty<\/th>\n<th>Phase 1 IND<\/th>\n<th>Phase 2 IND<\/th>\n<th>Phase 3 IND<\/th>\n<th>BLA<\/th>\n<th>Royalty<\/th>\n<\/tr>\n<tr>\n<td>$50,000<\/td>\n<td>$10,000<\/td>\n<td>$100,000<\/td>\n<td>$250,000<\/td>\n<td>$500,000<\/td>\n<td>$1,000,000<\/td>\n<td>6%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"info 9\">\n<table style=\"width: 100%;\"><\/table>\n<p>Kidney cancer is a type of cancer that starts in the kidney when cells in the body begin to grow out of control.<\/p>\n<table style=\"width: 100%;\">\n<tbody>\n<tr>\n<th>Upfront Fee<\/th>\n<th>Annual Minimum Royalty<\/th>\n<th>Phase 1 IND<\/th>\n<th>Phase 2 IND<\/th>\n<th>Phase 3 IND<\/th>\n<th>BLA<\/th>\n<th>Royalty<\/th>\n<\/tr>\n<tr>\n<td>$50,000<\/td>\n<td>$10,000<\/td>\n<td>$100,000<\/td>\n<td>$250,000<\/td>\n<td>$500,000<\/td>\n<td>$1,000,000<\/td>\n<td>6%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"info 10\">\n<table style=\"width: 100%;\"><\/table>\n<p>Lung cancer is cancer that forms in tissues of the lung, usually in the cells that line the air passages. It is the leading cause of cancer death in both men and women. There are two main types: small cell lung cancer and non-small cell lung cancer. These two types grow differently and are treated differently.<\/p>\n<table style=\"width: 100%;\">\n<tbody>\n<tr>\n<th>Upfront Fee<\/th>\n<th>Annual Minimum Royalty<\/th>\n<th>Phase 1 IND<\/th>\n<th>Phase 2 IND<\/th>\n<th>Phase 3 IND<\/th>\n<th>BLA<\/th>\n<th>Royalty<\/th>\n<\/tr>\n<tr>\n<td>$50,000<\/td>\n<td>$10,000<\/td>\n<td>$100,000<\/td>\n<td>$250,000<\/td>\n<td>$500,000<\/td>\n<td>$1,000,000<\/td>\n<td>6%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"info 11\">\n<table style=\"width: 100%;\"><\/table>\n<p>Non-small cell lung cancer is a group of lung cancers that behave similarly, such as squamous cell carcinoma and adenocarcinoma. Symptoms are a cough that won&#8217;t go away, shortness of breath, weight loss, or coughing up blood.<\/p>\n<table style=\"width: 100%;\">\n<tbody>\n<tr>\n<th>Upfront Fee<\/th>\n<th>Annual Minimum Royalty<\/th>\n<th>Phase 1 IND<\/th>\n<th>Phase 2 IND<\/th>\n<th>Phase 3 IND<\/th>\n<th>BLA<\/th>\n<th>Royalty<\/th>\n<\/tr>\n<tr>\n<td>$50,000<\/td>\n<td>$10,000<\/td>\n<td>$100,000<\/td>\n<td>$250,000<\/td>\n<td>$500,000<\/td>\n<td>$1,000,000<\/td>\n<td>6%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"info 12\">\n<table style=\"width: 100%;\"><\/table>\n<p>Mesothelioma is a rare condition that involves tumors growing in the mesothelium. This tissue covers the lungs, the heart and reproductive organs, as well as forming a cavity for the abdomen and those organs.<\/p>\n<table style=\"width: 100%;\">\n<tbody>\n<tr>\n<th>Upfront Fee<\/th>\n<th>Annual Minimum Royalty<\/th>\n<th>Phase 1 IND<\/th>\n<th>Phase 2 IND<\/th>\n<th>Phase 3 IND<\/th>\n<th>BLA<\/th>\n<th>Royalty<\/th>\n<\/tr>\n<tr>\n<td>$50,000<\/td>\n<td>$10,000<\/td>\n<td>$100,000<\/td>\n<td>$250,000<\/td>\n<td>$500,000<\/td>\n<td>$1,000,000<\/td>\n<td>6%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"info 13\">\n<table style=\"width: 100%;\"><\/table>\n<p>Ovarian cancer is a growth of cells that forms in the ovaries. The cells multiply quickly and can invade and destroy healthy body tissue.<\/p>\n<table style=\"width: 100%;\">\n<tbody>\n<tr>\n<th>Upfront Fee<\/th>\n<th>Annual Minimum Royalty<\/th>\n<th>Phase 1 IND<\/th>\n<th>Phase 2 IND<\/th>\n<th>Phase 3 IND<\/th>\n<th>BLA<\/th>\n<th>Royalty<\/th>\n<\/tr>\n<tr>\n<td>$50,000<\/td>\n<td>$10,000<\/td>\n<td>$100,000<\/td>\n<td>$250,000<\/td>\n<td>$500,000<\/td>\n<td>$1,000,000<\/td>\n<td>6%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"info 14\">\n<table style=\"width: 100%;\"><\/table>\n<p>Prostate cancer is one of the most common types of cancer among American men. The risk goes up as men age.<\/p>\n<table style=\"width: 100%;\">\n<tbody>\n<tr>\n<th>Upfront Fee<\/th>\n<th>Annual Minimum Royalty<\/th>\n<th>Phase 1 IND<\/th>\n<th>Phase 2 IND<\/th>\n<th>Phase 3 IND<\/th>\n<th>BLA<\/th>\n<th>Royalty<\/th>\n<\/tr>\n<tr>\n<td>$50,000<\/td>\n<td>$10,000<\/td>\n<td>$100,000<\/td>\n<td>$250,000<\/td>\n<td>$500,000<\/td>\n<td>$1,000,000<\/td>\n<td>6%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"info 15\">\n<table style=\"width: 100%;\"><\/table>\n<p>Stomach cancer, also known as gastric cancer, is a cancer that develops from the lining of the stomach.<\/p>\n<table style=\"width: 100%;\">\n<tbody>\n<tr>\n<th>Upfront Fee<\/th>\n<th>Annual Minimum Royalty<\/th>\n<th>Phase 1 IND<\/th>\n<th>Phase 2 IND<\/th>\n<th>Phase 3 IND<\/th>\n<th>BLA<\/th>\n<th>Royalty<\/th>\n<\/tr>\n<tr>\n<td>$50,000<\/td>\n<td>$10,000<\/td>\n<td>$100,000<\/td>\n<td>$250,000<\/td>\n<td>$500,000<\/td>\n<td>$1,000,000<\/td>\n<td>6%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"info 16\">\n<table style=\"width: 100%;\"><\/table>\n<p>Uterus or uterine cancer is also called endometrial cancer because it forms in the lining of your uterus, called the endometrium. All women are at risk for uterine cancer as long as they have a uterus, and the risk increases with age.<\/p>\n<table style=\"width: 100%;\">\n<tbody>\n<tr>\n<th>Upfront Fee<\/th>\n<th>Annual Minimum Royalty<\/th>\n<th>Phase 1 IND<\/th>\n<th>Phase 2 IND<\/th>\n<th>Phase 3 IND<\/th>\n<th>BLA<\/th>\n<th>Royalty<\/th>\n<\/tr>\n<tr>\n<td>$50,000<\/td>\n<td>$10,000<\/td>\n<td>$100,000<\/td>\n<td>$250,000<\/td>\n<td>$500,000<\/td>\n<td>$1,000,000<\/td>\n<td>6%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"info 17\">\n<table style=\"width: 100%;\"><\/table>\n<p>Medulloblastoma is a type of brain cancer that starts in the part of the brain called the cerebellum. Medulloblastoma is the most common type of cancerous brain tumor in children. Medulloblastoma (muh-dul-o-blas-TOE-muh) is a cancerous brain tumor that starts in the lower back part of the brain.<\/p>\n<table style=\"width: 100%;\">\n<tbody>\n<tr>\n<th>Upfront Fee<\/th>\n<th>Annual Minimum Royalty<\/th>\n<th>Phase 1 IND<\/th>\n<th>Phase 2 IND<\/th>\n<th>Phase 3 IND<\/th>\n<th>BLA<\/th>\n<th>Royalty<\/th>\n<\/tr>\n<tr>\n<td>$50,000<\/td>\n<td>$10,000<\/td>\n<td>$100,000<\/td>\n<td>$250,000<\/td>\n<td>$500,000<\/td>\n<td>$1,000,000<\/td>\n<td>6%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p>&nbsp;<br \/>\n<\/body><br \/>\n<\/html>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The following list of cancer immunotherapies are available for licensing under U.S. Patent Publication No.: 20220096542. Augmentation of Natural Killer Cell Activity and Induction of Cytotoxic Immunity Using Leukocyte Lysate Activated Allogeneic Dendritic Cells: StemVacs AbstractStimulation of immunity would be beneficial in various chronic conditions such as viral infections and neoplasia. Autologous dendritic cell therapy [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-215","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/stemvacs.therapeuticsolutionsint.com\/index.php\/wp-json\/wp\/v2\/pages\/215","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stemvacs.therapeuticsolutionsint.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/stemvacs.therapeuticsolutionsint.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/stemvacs.therapeuticsolutionsint.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stemvacs.therapeuticsolutionsint.com\/index.php\/wp-json\/wp\/v2\/comments?post=215"}],"version-history":[{"count":4,"href":"https:\/\/stemvacs.therapeuticsolutionsint.com\/index.php\/wp-json\/wp\/v2\/pages\/215\/revisions"}],"predecessor-version":[{"id":357,"href":"https:\/\/stemvacs.therapeuticsolutionsint.com\/index.php\/wp-json\/wp\/v2\/pages\/215\/revisions\/357"}],"wp:attachment":[{"href":"https:\/\/stemvacs.therapeuticsolutionsint.com\/index.php\/wp-json\/wp\/v2\/media?parent=215"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}