{"id":484,"date":"2024-11-07T16:13:50","date_gmt":"2024-11-07T16:13:50","guid":{"rendered":"https:\/\/stemvacs.therapeuticsolutionsint.com\/?page_id=484"},"modified":"2024-11-07T16:14:37","modified_gmt":"2024-11-07T16:14:37","slug":"melanoma-stemvacs-ipsc-chimera-a-gal","status":"publish","type":"page","link":"https:\/\/stemvacs.therapeuticsolutionsint.com\/index.php\/melanoma-stemvacs-ipsc-chimera-a-gal\/","title":{"rendered":"Melanoma &#8211; StemVacs-iPSC Chimera\/A-Gal"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Header&#8221; _builder_version=&#8221;4.21.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;gcid-3cfc8c0c-5557-4a5d-9dab-24e78d615311&#8243; custom_padding=&#8221;61px|||||&#8221; collapsed=&#8221;on&#8221; global_colors_info=&#8221;{%22gcid-3cfc8c0c-5557-4a5d-9dab-24e78d615311%22:%91%22background_color%22%93}&#8221; theme_builder_area=&#8221;post_content&#8221;][et_pb_row _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px||0px|||&#8221; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;][et_pb_text _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;-47px|||||&#8221; custom_padding=&#8221;2px||0px|||&#8221; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;]<\/p>\n<p>The following list of <strong>cancer immunotherapies<\/strong> are available for licensing under <a href=\"https:\/\/patents.justia.com\/patent\/20220403330\" target=\"_blank\" rel=\"noopener\">U.S. Patent Publication No.: <span>20220403330<\/span><\/a><span>.<\/span><\/p>\n<p><strong>Compositions Capable of Stimulating Immunity Towards Tumor Blood Vessels<\/strong><\/p>\n<div class=\"horizontal layout style-scope patent-result\">\n<div class=\"flex-3 style-scope patent-result\" marginright=\"\">\n<section id=\"abstract\" class=\"style-scope patent-result\">\n<div class=\"flex style-scope patent-result\">Abstract<\/div>\n<div class=\"layout horizontal style-scope patent-text\">\n<section id=\"text\" class=\"flex style-scope patent-text\"><span>Disclosed are novel means, protocols, and compositions of matter for eliciting an immune response against blood vessels supplying neoplastic tissue. In one embodiment pluripotent stem cells are transfected with one or more genes capable of eliciting immunity. In some embodiments such genes are engineered under control of specific promoters to allow for various specificities of activity. In one specific embodiment pluripotent stem cells engineered to endow properties capable of inducing expression of the \u03b1-Gal epitope (Gal\u03b11,3Gal\u03b11,4G1cNAc-R).<\/span><\/section>\n<\/div>\n<\/section>\n<\/div>\n<\/div>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;-99px|auto||auto||&#8221; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;][et_pb_text _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;-149px|||||&#8221; custom_padding=&#8221;46px|||||&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221; sticky_enabled=&#8221;0&#8243;]<html><br \/>\n<head><br \/>\n    <script src=\"https:\/\/ajax.googleapis.com\/ajax\/libs\/jquery\/1.12.4\/jquery.min.js\"><\/script><br \/>\n    <script>\n        $(function() {\n            $('.info').hide();\n            $('#countryList').on('change', function() {\n                $('.info').hide();\n                var countryCode = $('#countryList').val();\n                $('.info.' + countryCode).show();\n            });\n        });\n    <\/script><br \/>\n<\/head><br \/>\n<body><br \/>\n<select id=\"countryList\"><option value=\"\">[Select Disease]<\/option><option value=\"2\">Melanoma<\/option><option value=\"3\">Juvenile melanoma<\/option><option value=\"4\">Lentigo maligna melanoma<\/option><option value=\"5\">Malignant melanoma<\/option><option value=\"6\">Acral-lentiginous melanoma<\/option><option value=\"7\">Amelanotic melanoma<\/option><option value=\"8\">Benign juvenile melanoma<\/option><option value=\"9\">Nodular melanoma subungal melanoma<\/option><option value=\"10\">Superficial spreading melanoma<\/option><\/select><\/p>\n<div class=\"info 2\">\n<table style=\"width:100%\">\n<table style=\"width:100%\">\n<tr>\n<th>Upfront Fee<\/th>\n<th>Annual Minimum Royalty<\/th>\n<th>Phase 1 IND<\/th>\n<th>Phase 2 IND<\/th>\n<th>Phase 3 IND<\/th>\n<th>BLA<\/th>\n<th>Royalty<\/th>\n<\/tr>\n<tr>\n<td>$50,000<\/td>\n<td>$10,000<\/td>\n<td>$100,000<\/td>\n<td>$250,000<\/td>\n<td>$500,000<\/td>\n<td>$1,000,000<\/td>\n<td>6%<\/td>\n<\/tr>\n<p>Melanoma  is a dangerous type of skin cancer that develops from melanocytes, the cells that produce melanin, the pigment that gives skin and hair their color.<br \/>\n<\/table>\n<\/div>\n<div class=\"info 3\">\n<table style=\"width:100%\">\n<table style=\"width:100%\">\n<tr>\n<th>Upfront Fee<\/th>\n<th>Annual Minimum Royalty<\/th>\n<th>Phase 1 IND<\/th>\n<th>Phase 2 IND<\/th>\n<th>Phase 3 IND<\/th>\n<th>BLA<\/th>\n<th>Royalty<\/th>\n<\/tr>\n<tr>\n<td>$50,000<\/td>\n<td>$10,000<\/td>\n<td>$100,000<\/td>\n<td>$250,000<\/td>\n<td>$500,000<\/td>\n<td>$1,000,000<\/td>\n<td>6%<\/td>\n<\/tr>\n<p>Juvenile melanoma, also known as melanoma in children, is a rare but common skin cancer in children.<br \/>\n<\/table>\n<\/div>\n<div class=\"info 4\">\n<table style=\"width:100%\">\n<table style=\"width:100%\">\n<tr>\n<th>Upfront Fee<\/th>\n<th>Annual Minimum Royalty<\/th>\n<th>Phase 1 IND<\/th>\n<th>Phase 2 IND<\/th>\n<th>Phase 3 IND<\/th>\n<th>BLA<\/th>\n<th>Royalty<\/th>\n<\/tr>\n<tr>\n<td>$50,000<\/td>\n<td>$10,000<\/td>\n<td>$100,000<\/td>\n<td>$250,000<\/td>\n<td>$500,000<\/td>\n<td>$1,000,000<\/td>\n<td>6%<\/td>\n<\/tr>\n<p>Lentigo maligna melanoma is a type of skin cancer that develops from a lentigo maligna, a precancerous condition.<br \/>\n<\/table>\n<\/div>\n<div class=\"info 5\">\n<table style=\"width:100%\">\n<table style=\"width:100%\">\n<tr>\n<th>Upfront Fee<\/th>\n<th>Annual Minimum Royalty<\/th>\n<th>Phase 1 IND<\/th>\n<th>Phase 2 IND<\/th>\n<th>Phase 3 IND<\/th>\n<th>BLA<\/th>\n<th>Royalty<\/th>\n<\/tr>\n<tr>\n<td>$50,000<\/td>\n<td>$10,000<\/td>\n<td>$100,000<\/td>\n<td>$250,000<\/td>\n<td>$500,000<\/td>\n<td>$1,000,000<\/td>\n<td>6%<\/td>\n<\/tr>\n<p>Malignant melanoma, also known as melanoma, is a dangerous type of skin cancer that can develop from melanocytes, the cells that produce melanin and give skin its color.<br \/>\n<\/table>\n<\/div>\n<\/table>\n<\/div>\n<div class=\"info 6\">\n<table style=\"width:100%\">\n<table style=\"width:100%\">\n<tr>\n<th>Upfront Fee<\/th>\n<th>Annual Minimum Royalty<\/th>\n<th>Phase 1 IND<\/th>\n<th>Phase 2 IND<\/th>\n<th>Phase 3 IND<\/th>\n<th>BLA<\/th>\n<th>Royalty<\/th>\n<\/tr>\n<tr>\n<td>$50,000<\/td>\n<td>$10,000<\/td>\n<td>$100,000<\/td>\n<td>$250,000<\/td>\n<td>$500,000<\/td>\n<td>$1,000,000<\/td>\n<td>6%<\/td>\n<\/tr>\n<p>Acral-lentiginous melanoma is a specific type of melanoma that appears on the palms of the hands, the soles of the feet, or under the nails.<br \/>\n<\/table>\n<\/div>\n<div class=\"info 7\">\n<table style=\"width:100%\">\n<table style=\"width:100%\">\n<tr>\n<th>Upfront Fee<\/th>\n<th>Annual Minimum Royalty<\/th>\n<th>Phase 1 IND<\/th>\n<th>Phase 2 IND<\/th>\n<th>Phase 3 IND<\/th>\n<th>BLA<\/th>\n<th>Royalty<\/th>\n<\/tr>\n<tr>\n<td>$50,000<\/td>\n<td>$10,000<\/td>\n<td>$100,000<\/td>\n<td>$250,000<\/td>\n<td>$500,000<\/td>\n<td>$1,000,000<\/td>\n<td>6%<\/td>\n<\/tr>\n<p>Amelanotic melanoma, these skin lesions lack melanin, the dark pigment that gives most moles and melanomas their color. Instead, amelanotic melanomas can be clear, white or skin-colored, sometimes with a slight pink, purple or red tint.<br \/>\n<\/table>\n<\/div>\n<div class=\"info 8\">\n<table style=\"width:100%\">\n<table style=\"width:100%\">\n<tr>\n<th>Upfront Fee<\/th>\n<th>Annual Minimum Royalty<\/th>\n<th>Phase 1 IND<\/th>\n<th>Phase 2 IND<\/th>\n<th>Phase 3 IND<\/th>\n<th>BLA<\/th>\n<th>Royalty<\/th>\n<\/tr>\n<tr>\n<td>$50,000<\/td>\n<td>$10,000<\/td>\n<td>$100,000<\/td>\n<td>$250,000<\/td>\n<td>$500,000<\/td>\n<td>$1,000,000<\/td>\n<td>6%<\/td>\n<\/tr>\n<p>Benign juvenile melanoma  is an old term for a rare, noncancerous mole called a Spitz nevus.<br \/>\n<\/table>\n<\/div>\n<div class=\"info 9\">\n<table style=\"width:100%\">\n<table style=\"width:100%\">\n<tr>\n<th>Upfront Fee<\/th>\n<th>Annual Minimum Royalty<\/th>\n<th>Phase 1 IND<\/th>\n<th>Phase 2 IND<\/th>\n<th>Phase 3 IND<\/th>\n<th>BLA<\/th>\n<th>Royalty<\/th>\n<\/tr>\n<tr>\n<td>$50,000<\/td>\n<td>$10,000<\/td>\n<td>$100,000<\/td>\n<td>$250,000<\/td>\n<td>$500,000<\/td>\n<td>$1,000,000<\/td>\n<td>6%<\/td>\n<\/tr>\n<p>Nodular melanoma subungal melanoma is a rare and aggressive form of skin cancer that can appear as a nodule under the nail.<br \/>\n<\/table>\n<\/div>\n<div class=\"info 10\">\n<table style=\"width:100%\">\n<table style=\"width:100%\">\n<tr>\n<th>Upfront Fee<\/th>\n<th>Annual Minimum Royalty<\/th>\n<th>Phase 1 IND<\/th>\n<th>Phase 2 IND<\/th>\n<th>Phase 3 IND<\/th>\n<th>BLA<\/th>\n<th>Royalty<\/th>\n<\/tr>\n<tr>\n<td>$50,000<\/td>\n<td>$10,000<\/td>\n<td>$100,000<\/td>\n<td>$250,000<\/td>\n<td>$500,000<\/td>\n<td>$1,000,000<\/td>\n<td>6%<\/td>\n<\/tr>\n<p>Superficial spreading melanoma is a type of skin cancer that is the most common form of melanoma, accounting for 70\u201380% of cases.<br \/>\n<\/table>\n<\/div>\n<p><\/body><br \/>\n<\/html>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The following list of cancer immunotherapies are available for licensing under U.S. Patent Publication No.: 20220403330. Compositions Capable of Stimulating Immunity Towards Tumor Blood Vessels Abstract Disclosed are novel means, protocols, and compositions of matter for eliciting an immune response against blood vessels supplying neoplastic tissue. In one embodiment pluripotent stem cells are transfected with [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-484","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/stemvacs.therapeuticsolutionsint.com\/index.php\/wp-json\/wp\/v2\/pages\/484","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stemvacs.therapeuticsolutionsint.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/stemvacs.therapeuticsolutionsint.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/stemvacs.therapeuticsolutionsint.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stemvacs.therapeuticsolutionsint.com\/index.php\/wp-json\/wp\/v2\/comments?post=484"}],"version-history":[{"count":3,"href":"https:\/\/stemvacs.therapeuticsolutionsint.com\/index.php\/wp-json\/wp\/v2\/pages\/484\/revisions"}],"predecessor-version":[{"id":488,"href":"https:\/\/stemvacs.therapeuticsolutionsint.com\/index.php\/wp-json\/wp\/v2\/pages\/484\/revisions\/488"}],"wp:attachment":[{"href":"https:\/\/stemvacs.therapeuticsolutionsint.com\/index.php\/wp-json\/wp\/v2\/media?parent=484"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}